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The core ofthe nucleosome consists ofeight histonemolecules (called an octamer). An equivalent of THx was also able to detect the lower limit of cerebral autoregula-tion in an experimental piglet model (76) and impaired cerebrovascular pressure reactivityin TBI patients (defined PRx < 0.3) (78). Using asingle-center prospective study, the authors identifi ed atotal of ten patients over a period of 18 months

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Thisvagusstoff was found in 1926 to be acetylcho-line, which earlier Dale (1914) had characterisedas ‘parasympathomimetic’.

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